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Glossary term
Tadalafil
Also known as Cialis - Adcirca
Long-acting PDE5 inhibitor and the generic form of Cialis. 24-36 hour clinical window, daily or on-demand.
Tadalafil has a plasma half-life of ~17.5 hours - the longest in the PDE5 class - producing a 24-36 hour clinical window. Also approved for BPH symptoms at daily low dosing (2.5-5 mg). Response rates at 70-80% for organic ED. Same contraindications as sildenafil: no nitrates, no riociguat, cardiovascular clearance required. Many members prefer daily dosing because it removes the timing conversation entirely.
Medically reviewed byDr. Lena Okafor, MD
Medical Director - updated April 2026How we review
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