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Glossary term
Sirtuins
NAD-dependent enzymes (SIRT1-7) linked to stress response and aging. Strong rodent data, weaker in humans.
Sirtuins are a family of seven NAD+-dependent enzymes (SIRT1-SIRT7) that regulate cellular stress response, metabolism, and DNA repair. Each sits in a different compartment - nucleus, mitochondria, cytosol - and tunes gene expression in response to energy state. Rodent data ties sirtuin activity to extended lifespan, especially SIRT1 and SIRT6; human translation is promising but not conclusive. Raising NAD+ with NR or NMN is one of the cleanest ways to support sirtuin function, which is the premise behind most of the longevity supplement market. Run the Advanced panel first - ApoB and HbA1c move longevity outcomes more today.
Medically reviewed byDr. Lena Okafor, MD
Medical Director - updated April 2026How we review
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