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Glossary term
NAD
Also known as Nicotinamide adenine dinucleotide - NAD
A coenzyme that powers mitochondria and DNA repair - drops ~50% between age 30 and 70.
Nicotinamide adenine dinucleotide (NAD+) is rate-limiting for mitochondrial energy production, PARP-mediated DNA repair, and sirtuin signaling. Cellular NAD+ declines with age, driving interest in precursors like NR and NMN or direct subcutaneous NAD+. Oral NR at 300-900 mg/day raises NAD+ metabolites 2-3x in multiple human trials; NMN data is newer but trending the same direction. Subcutaneous NAD+ bypasses first-pass metabolism and works well for supervised cycles. Clinical outcome evidence - lifespan, disease prevention - remains early. Run the Advanced panel first; ApoB, HbA1c, and fasting insulin move outcomes more than NAD does today.
- Symbol
- NAD+
Medically reviewed byDr. Lena Okafor, MD
Medical Director - updated April 2026How we review
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